Responses to eden mor exposed

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Nevertheless, other stressful stimuli, such as hypoxia, toxic chemicals, and inflammation, also induce HSP expression. Intriguingly though, initial studies in adjuvant arthritis, a Mycobacterium tuberculosis induced arthritis, demonstrated that immunisation with the dominant mycobacterial antigen, HSP60, abrogated subsequently induced disease. Journal List Ann Rheum Dis v. Clin Exp Rheumatol 11 61— Protective effects of bacterial HSP immunisations could be due to the high homology of the protein.

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HSP immunisations have been shown to inhibit autoimmune disorders such as diabetes and arthritis both in animal models and in initial clinical trials in patients with chronic inflammatory disease.

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Heat shock proteins induce T cell regulation of chronic inflammation

Ann N Y Acad Sci — Int Rev Immunol 24 3—4 — Crit Rev Immunol 24 — As described above HSPs have the ability to directly interact with different cells of the immune system by triggering TLR. Arthritis Rheum 50 — These cells will induce an anergic state in these HSP specific T cells. Moreover, transfer of T cells with irrelevant TCR specificity did not abolish the development of PGIA when transduced with the same construct, emphasising the importance of antigen specificity of the regulatory T cells Guichelaar et alunpublished results,

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